Ovarian cancer

Of all gynecologic malignancies, ovarian crabmeat continues to concord the highest death rate rate and is the most difficult to diagnose. In the United States pistillate population, ovarian raisecer ranks fifth in absolute mortality among genus Cancer related deaths (13,000/yr). In most reported cases, ovarian cancer, when first diagnosed is in stages 3 or IV in about 60 to 70% of patients which further complicates treatment of the affection (Barber, 3). Early detection in ovarian cancer is hampered by the lack of appropriate tumor markers and clinically, most patients fail to feature significant symptoms until they reach advanced stage disease. The characteristics of ovarian cancer have been studied in primary tumors and in effected ovarian tumor cellular telephone lines which provide a reproducible source of tumor material. Among the major clinical problems of ovarian cancer, malignant progression, rapid emergence of drug resistance, and associated cross-resist ance remain unresolved. ovarian cancer has a high frequency of metastasis yet mainly remains situate within the peritoneal cavity. Tumor development has been associated with aberrant, dysfunctional view and/or mutation of various genes. This can include oncogene overexpression, increase or mutation, aberrant tumor suppressor expression or mutation. Also, subversion of forces antitumor repellent responses may play a contribution in the pathogenesis of cancer (Sharp, 77). Ovarian clear cell glandular carcinoma was first caste forth by Peham in 1899 as hypernephroma of the ovary because of its resemblance to renal cell carcinoma. By 1939, Schiller state a histologic parity to mesonephric tubules and classified these tumors as mesonephromas. In 1944, Saphir and Lackner described two cases of hypernephroid carcinoma of the ovary and proposed clear cell glandular cancer as an alternative term. Clear cell tumors of the ovary are direct generally considered to be of mu llerian and in the genital tract of mulleria! n origin. A number of examples of clear cell adenocarcinoma have been... If you requirement to get a full essay, array it on our website: OrderCustomPaper.com

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